Methyl B-12 10,000 mcg - Pharmacokinetic (pK) Study
Bioavailability Study
Methyl B-12 is a co-enzyme form of vitamin B-12 (cobalamin) necessary for the production of energy from fats and proteins. It plays a critical role in DNA synthesis, as well as in homocysteine metabolism.* Three healthy adult volunteers 22 to 58 years old participated in a clinical trial to study the bioavailability of Methyl B-12, a dietary supplement from NOW® (item # 0501). Serum cobalamin was measured at baseline, and again at 1, 3, 7 and 24 hours following oral administration of one lozenge providing 10,000 mcg of vitamin B-12.
Results
Average cobalamin level was increased one hour after administration, and peaked seven hours following administration, reaching 54% above the baseline level. Average cobalamin concentration remained 17% above the baseline level 24 hours post-supplementation. This study confirms the exceptional bioavailability of NOW® Methyl B-12.
Time, hours
Serum cobalamin pg/ml
0
600
2
900
4
950
6
1025
8
1050
10
1025
12
1000
14
950
16
900
18
850
20
800
22
775
24
750
Average serum cobalamin level before, and at 1, 3, 7 and 24 hours following a single administration of one Methyl B-12 lozenge (NOW®, Bloomingdale, IL; item # 0501) providing 10,000 mcg of methylcobalamin in healthy adult volunteers.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
