Pantethine 300 mg - Pharmacokinetic (pK) Study
Bioavailability study
Pantethine is a form of pantothenic acid (vitamin B5), which plays a role in the formation of coenzyme A (CoA).* It also helps to support proper cholesterol production and a healthy mode of fat storage in the liver.* Three healthy adult volunteers 30 to 52 years old participated in a clinical trial to study the bioavailability of Pantethine, a dietary supplement from NOW® (item # 0487). Serum pantothenic acid was measured at baseline, and at 1, 2, 3 and 6 hours following oral administration of 1 softgel providing 300 mg of Pantethine.
Results
Average serum pantothenic acid increased one hour after administration, and peaked two hours following administration, reaching 321% above baseline level. Average pantothenic acid concentration remained elevated for the duration of the study, 134% above the baseline level six hours post-supplementation. The study confirms the exceptional bioavailability of NOW® Pantethine.
Time, hours
Pantothenic acid, ng/mL
0
50
1
200
2
230
3
190
4
160
5
120
6
110
Average serum pantothenic acid level following oral administration of a single Pantethine Softgel (NOW®, # 0487 providing 300 mg of Pantethine) in healthy adult volunteers.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
